Penicillin was discovered in 1928 and developed for medical use in the early 1940s as a potent weapon against Staphylococcus of various sorts. But by 1955, penicillin- resistant strains of staph were turning up, especially in hospitals, from Sydney to Seattle.
Methicillin, introduced in 1959, was especially useful against the penicillin-resistant Staphylococcus aureus. But by 1972 methicillinresistant Staphylococcus aureus had appeared in England, the United States, Poland, Ethiopia, India, and Vietnam.
Vancomycin, introduced in 1972, was named for its capacity to vanquish even bugs that resisted earlier drugs. But by the late 1980s vancomycin resistance had shown up in Enterococcus bacteria in the form of a gene called vanA, and within another decade vanA had jumped sideways across genus boundaries from Enterococcus into staph, including Staphylococcus aureus. By 1996 there…
